Source: Fiziologia - Physiology.
The strongest risk factors are family history of melanoma, multiple pre-existent melanocytic nevi, previous melanoma, previous nonmelanoma skin cancer. Based on the histological features, primary cutaneous melanomas have been classified in four types. The major histologic subtypes of melanoma are superficial spreading melanoma, nodular melanoma, lentigo melanoma and acral lentiginous melanoma.
Early diagnosed, melanoma has a good prognosis, beeing completely cured in the early aggressive cancer lymph nodes by operation. In order to facilitate the early recognition of potentially curable cutaneous malignant melanoma, the ABCDE acronym is a easy tool provided.
The Clinical features described are: Asymmetry, Border irregularity, Color variegation, Diameter greater than 6 mm and Evolving, which recognize the dynamic nature of the skin malignacy. During the melanomogenesis process, histological changes are accompanied by biological events, molecular lesions and genetic alterations.
Starting aggressive cancer lymph nodes the formation of benign nevus, and then progressing to the junctional melanocytic hyperplasia and then aberrant differentiation, a mutation of BRAF gene and hepatic cancer meaning of the MAPK signaling pathway take place.
The switch from radial growth phase to vertical growth phase is the most crucial step in melanoma tumorigenesis, commonly associated with subsequent metastatic disease.
The metastatic melanoma is the last stage, when the metastatic tumor enter the lymphatic and blood circulation and metastasize to other organs like lymph nodes, brain, liver or lung.
Galentin-3 and Galentin-1, are two members of galentin family which are directly corelated with the metastatic potential of melanomas. The review seeks to examine melanoma progression and some molecular changes that accompanied the process. Also, a histologic classification and prevention and early recognition of melanoma are beeing discussed.
What Are The Survival Rates For Lymphoma?
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[Differentiated thyroid cancer--staging and prognostic systems].
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