Colorectal cancer genes involved

We also genotyped females and 62 males, who formed the control group. Genotyping results were related to environmental risk factors, smoking habit and diet.

A significantly increased risk for CRC was observed in females and males with high daily fried red meat intake, carriers of the ArgGln OR 2.


Conclusions: In Romanians, the association between the mutated genotypes and environmental risk factors modulates the risk for sporadic CRC. Smoking in association with the ArgGln-XRCC1 genetic variation influences the early onset of sporadic colorectal cancer in females.

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  • Factorii de risc ai cancerului colorectal

Rezumat Introducere: Variațiile genetice, cum ar fi cele care influențează sistemele de reparare a defectelor de replicare a ADN, pot reprezenta factori de susceptibilitate în cancerul colorectal sporadic CCR ca urmare a interacțiunii cu factori de mediu. Am determinat de asemenea, genotipurile pentru femei și 62 bărbațicare au format grupul de colorectal cancer genes involved.

Rezultatele au fost analizate din punct de vedere al relației cu factorii de risc de mediu, fumatul și dieta. Rezultate: Bărbații fumători purtători ai variațiilor genetice ArgGln, LysGln, MetThr au avut un risc semnificativ crescut de 4.

Revista Romana de Medicina de Laborator

Un risc semnificativ crescut de a dezvolta cancer colorectal sporadic a fost observat în cazul femeilor și bărbaților cu o dietă bogată în carne roșie prăjită purtători oxiuros o que e variațiilor genetice ArgGln OR 2. Femeile a căror dietă a inclus cantități mari de carne roșie prăjită au avut un risc semnificativ crescut de a dezvolta timpuriu cancer colorectal sporadic dacă au fost purtătoare a variațiilor genetice ArgGln-XRCC1 OR 5.

Concluzii: În cazul populației de origine română, asocierea genotipurilor mutante cu factori de mediu modulează riscul pentru CCR sporadic.

Although the causes of this disease are not entirely understood, it is known that several factors influence its occurrence. Risk factors for colorectal cancer include age, family history of colon polyps, inflammatory bowel disease and hereditary syndromes, smoking, obesity, sedentarism, alcohol consumption.

La femei, fumatul în asociere cu variația genetică ArgGln-XRCC1 influențează debutul timpuriu al cancerului colorectal sporadic. Smoking exposure as a risk factor for prevalent and recurrent colorectal adenomas. Cancer Epidemiol Biomarkers Prev.

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Google Scholar 2. Prevalence of colorectal neoplasia in smokers.

colorectal cancer genes involved

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Colorectal Cancer Gene Screens

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J Appl Genet. Polski Przegląd Chirurgiczny. XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk.

In Romania, the incidence of CRC in is We reviewed a series of studies that are related to colon cancer and studied the epithelial-mesenchymal transition at the front of tumor invasion EMT. Cellular phenotypic changes characteristic of EMT can be induced by the absence of transition cofactor p involved in cellular regulation. Loss of syndecan-1 marker is associated with local tumor stage and metastasis.

DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps. Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk.

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colorectal cancer genes involved

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