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Current treatment for advanced HCC includes mainly sorafenib and hepatocellular cancer trial recently approved regorafenib and nivolumab, as chemotherapy has shown little benefit.

However, the hepatocellular cancer trial benefit and the low response rate from systemic treatments suggest an increased need for new strategies.

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Recent scientific advances indicate a potential benefit from immunotherapy in hepatocellular carcinoma, due to its immunogenicity. Hepatocellular cancer trial trials have evaluated both immunotherapy as monotherapy and the combination with other targeted systemic treatments or local strategies.

  1. Liver helminth infection
  2. Papillomavirus causes et symptomes
  3. Verslype 1,2O.

The present article reviews current clinical data regarding the possible role of immunotherapy in HCC management and future directions for clinical research. Global cancer statistics CA Cancer J Clin ; 65 2 hepatocellular cancer trial Early detection of liver cancer: diagnosis and management.

hepatocellular cancer trial

Curr Gastroenterol Rep ; 10 1 : Known, new and emerging risk factors of hepatocellular carcinoma review. Presse Med ; 46 11 : Natural history of un-treated nonsurgical hepatocellular carcinoma: Rationale hepatocellular cancer trial the design and evaluation of therapeutic trials.

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Hepatology ; 29 1 : Medicine ; 95 11 : e Sorafenib in Advanced Hepa-tocellular Carcinoma. N Engl J Med ; 4 : Regorafenib for patients with hepa-tocellular carcinoma who progressed on sorafenib treatment RESORCE : a randomized, double-blind, placebo-controlled, phase 3 trial.

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Lancet ; 7 : Lancet ; 24 : Cell papilloma virus vaccino maschi lombardia 7 : Cancer genome landscapes. Science ; : Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carci-noma.

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J Immunol ; 8 : Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy.

Miron, M. HCC incidence has doubled over the last 20 years in Europe. The management of HCC patients depends mainly on the extent and location of the tumor and the underlying liver disease. Three curative methods are currently available: orthotopic liver transplantation, surgical resection and local destruction. Local destruction of HCC is the most recent curative treatment that may be done using chemical alcohol or acetic acid or physical destruction by thermal ablation cryotherapy, radiofrequency.

Nat Rev Cancer ; 12 4 : Hepatology ; 59 2 : Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation. J Hepatol ; 45 2 : A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

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J Hepatol ; 59 1 : Tremelimumab in combination with hepatocellular cancer trial in patients with advanced hepatocellular carcinoma. J Hepatol ; 66 3 : Gastroenterology ; 7 : Gale M, editor.

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PLoS Pathog hepatocellular cancer trial 5 2 : e A randomized phase II study to assess the effectiveness of fluid therapy or intensive nutritional support on hepatocellular cancer trial in patients with advanced cancer who cannot be nourished via enteral route.

J Palliat Med ; Cancer Res ; 66 2 : Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.

hepatocellular cancer trial

Nature ; : Programmed death ligand 1 expression in hepatocellular carcinoma: Relationship With clinical and pathological features. Hepatology ; 64 6 :