Tratamentul carcinoamelor de planşeu oral anterior
Frequently, a mandible resection is required in order to obtain safe oncologic margins. The prognosis is good, with a higher overall survival rate than in other oral malignancies.
Keywords carcinoma, floor of the mouth, mandible resection, neck dissection Rezumat Cu o prevalenţă inferioară tumorilor maligne ale limbii, tumorile maligne de planşeu anterior impun o abordare chirurgicală la fel de radicală, cu o margine de siguranţă mare şi cu managementul problemelor de la nivelul gâtului.
Datorită localizării lor hpv in lip, sunt mai uşor de diagnosticat, iar pacientul se prezintă şi în stadii incipiente, nu doar în stadii tardive. Frecvent, este necesară rezecţia mandibulei, pentru a obţine margini de siguranţă oncologică.
Prognosticul este bun, cu o supravieţuire generală mai hpv in lip decât în cazul altor malignităţi orale. Cuvinte cheie carcinom planşeu oral rezecţie de mandibulă evidare cervicală Introduction Oral cancer is the most encountered tumor in head and neck region.
It usually affects male patients in their 6th decade of life 1a hpv in lip explanation for this gender imbalance hpv in lip related to smoking and drinking, which are more frequent in men.
It is age-related, the 5th and 6th decade of life seems to be the most encountered, but in the last years there is a growing tendency in younger adults years old, below Also, strong hpv in lip are emerging concerning HPV infection and oral carcinoma, especially the 16th subtype seems to be involved in cancer pathology 2.
What is sure is that HPV in oncologic hpv in lip is a negative prognosis factor.
Diagnosis Before developing cancer tumors, patients can present with mucosal lesions such as leukoplakia, erythroplakia or a combination of the two. Sometimes the onset is missed by the doctor or the patient, as it can mimic numerous benign conditions, but as it develops, the signs of malignancy are more pronounced solid mass, infiltrative, ulcerated lesionand it will generally present in one of the two main stages: exophytic or endophytic.
For radiological assessment of the cancer patients, the most implied methods are CT scanning for bony invasion and MRI for muscles involvement and to accurately determine the cervical metastasis.
The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated.
PET-CT is a more advanced type of tissue scanning, better suited for preoperative staging, although with a higher cost than normal scans, and it gives clinicians more precise information 4. Cervical metastasis, due to a higher intake of glucose, can be easier detected, as many PET diagnosed occult metastases proved to be malignant at the histological HP report, but sometimes negative masses in PET scan were also found to be positive at the HP examination.
Ce este cancerul buzelor?
It is not a total bullet proof investigation, but is a powerful tool when dealing with cancer patients. The treatment implies a surgical phase and adjuvant oncological therapy.
Even late stages can be surgically cured and the remaining defects reconstructed with the aid of free flaps. The prognosis depends hpv in lip the negative resection margins 6thus having a safe oncological margin of more than 5 mm and lack of margin dysplasia. Because there are situated in the proximity of the lingual cortex, in many cases hpv in lip en bloc mandible resection should be performed even in earlier stages.
- Chisturi de giardia
- Sirop antihelmintic
Usually, a continuity sparing resection is performed; a segmental resection in moderate stages would not grant an extra benefit regarding the oncologic prognosis, but it will inflict a greater impairment hpv in lip the patient due to muscle attachment loss 7. In early stages, the cervical metastases are not that frequent, but in advanced tumors the neck must be carefully checked.
Tratamentul carcinoamelor de planşeu oral anterior
When the diagnosis is N0 for hpv in lip metastasis, depending on the tumor pattern, an elective neck dissection can be performed SOH dissectionconsidered to have the same benefits as a radical dissection 8. Most of the cervical metastases are found in the first three lymphatic levels, so a SOH neck dissection will provide a proper outcome.
Un studiu privind vaccinul anti-HPV, vaccin ce previne cancerul de col uterin, arată că rata de succes a acestuia și speranța că acest tip de cancer ar putea fi eradicat în viitorul nu foarte îndepărtat. Cercetătorii au mai descoperit și că vârsta este un factor important în succesul acestui vaccin: imunizarea fetelor în vârstă de 12 hpv in lip este de aproape două ori mai eficientă decât imunizarea adolescentelor de 17 ani. Fetele și adolescenetele sunt vaccinate contra virusului HPV în Anglia, iar Scoția a introdus programul național de imunizare contra HPV înpe fetele de ani.
Adjuvant radiotherapy and chemotherapy are performed when positive margins are found, or the tumor has a vascular or neural proliferation. Regarding the cervical metastases, adjuvant therapy is applied when there is a positive carcinoma involvement, irrespective of capsule integrity 9.
Diagnosticul, tratamentul si urmarirea leziunilor precanceroase de col uterin
Radiotherapy as first therapy is employed in advanced stages where surgical cure cannot be performed, as a palliative treatment or for tumor conversion.
Case 1 Figure 1. Case 1.
Above — hpv in lip FOM tumor. Below left — CT scan, no bony invasion. Below right —month check up, no relapse A year-old patient presented for a floor of the mouth FOM swelling, with a 3-month duration. The patient had an ulcerated fixed tumor mass with irregular shape and borders, with pain on palpation, without any clinical signs of cervical cancerul pulmonar curs amg. A biopsy was taken squamous carcinoma and an en bloc resection with marginal hpv in lip resection was performed, with primary closure.