Metastatic cancer hereditary. Cancerul pancreatic

The benefits are certain in some cases: life years gained for those with curable disease, avoidance of morbidity, reassurance that the disease is at a very early stage, avoiding expenses of treatment for advanced cancers and extra years of productivity. But screening tests also have disadvantages, so a balanced decision must be made, with the help of clinical randomized trials.

In this article I will present the current methods for screening accepted for general population and particular screening reserved for persons at high risk.

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Although in the first case the benefit is proven, the use of metastatic cancer hereditary methods in practice varies largely due to lack of resources and well designed health programs.

Beneficiile sunt evidente în anumite cazuri: prelungirea su­pravieţuieii la cei cu boală curabilă, scăderea morbidităţii, asigurarea pacientului că boala se află în stadiu incipient, evitarea costurilor crescute asociate cu tratamentul for­melor avansate de viermi rotunzi şi creşterea numărului de ani de productivitate. Dar testele de screening au şi dezavantaje, aşa că un echilibru trebuie găsit, cea mai importantă con­tribuţie în acest sens fiind dată de testele clinice ran­do­mizate.

În acest articol voi prezenta metodele curente acceptate pentru populaţia generală şi cele rezervate pentru persoanele cu risc înalt. metastatic cancer hereditary

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Deşi în primul caz beneficiile sunt dovedite, utilizarea metastatic cancer hereditary în practică variază larg metastatic cancer hereditary cauza lipsei de resurse şi a lipsei implementării programelor de sănătate publică. Checking for cancer or for conditions that may become cancer in people who have no symptoms is called scre­ening.

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It is usually assimilated with secondary metastatic cancer hereditary and involves the use of diagnostic tests in an apparently healthy population. Many people wrongly mistake screening for prevention 2. There are several forms metastatic cancer hereditary prevention: Primary prevention - aims to prevent disease before it ever occurs. This is done by preventing exposures to hazards that cause the disease, altering unhealthy or unsafe behaviors that can lead to disease, and increasing resistance to disease if exposure occurs.

One example is vaccination 3. Secondary level of prevention - treatment of precancerous or cancerous lesions in early stages, when no clinical expression is present, which leads to avoidance of developing invasive or metastatic disease.

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It includes screening asymptomatic patient and early detection diagnose in phase of minimal symptoms of disease. It also applies to advanced disease which is asymptomatic metastatic cancer hereditary without complications at time being.

The fourth level of prevention - according to some authors, could be considered prevention of suffering metastatic cancer hereditary side effects of treatment and complications, pain and maintaining the quality of life of the patients 4. Screening can be proposed for a certain cancer in the following situations: if it is frequent, has a long preclinical evolution, is associated with increased mortality and morbidity, long preclinical non-metastasis faze and if early detection offers access to treatment that improves outcomes.

It is important to remind that screening tests can have potential harms as well as benefits.

This type of cancer has a high mortality, and the overall survival is also low. In these conditions, researchers are always looking for improving the therapy.

Some screening tests may have side effects, cause discomfort or severe complications. Screening tests can have false-positive results.

Un astfel de diagnostic nu poate fi prevenit in totalitate, in ciuda oricaror eforturi pe care le facem pentru a ne imbunatati stilul de viata. Dincolo de alimentatie, sport, renuntarea la vicii si reducerea stresului, exista factorul genetic ereditar, acel aspect pe care nu il metastatic cancer hereditary influenta. Avem insa la indemana testari genetice care ne pot indica daca genele noastre ne trag un semnal de alarma in privinta unei predispozitii, pentru unul sau mai multe tipuri de cancer.

Screening tests can have false-negative results. Overdiagnosis is possible. This happens when a screening test correctly shows that a person has cancer, but the cancer is metastatic cancer hereditary growing and would not have harmed that person in his or her lifetime.

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This can lead to overtreatment 5. Screening tests that have been shown to reduce cancer deaths Colonoscopy, sigmoidoscopy, and fecal occult blood tests FOBTs Colon cancer is the third most frequent cancer in both men and women.

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Although usually met in persons after 50 years, there is a trend o increase incidence among metastatic cancer hereditary adults. The major risk factors are family history and old age, other conditions being associated with greater probability of cancer alcohol, smoking, lack of physical exercise, poor fiber diet and rich in red processed meat. Another risk is found in people with ulcerative colitis and Crohn disease 6.

Genetic consult, thorough history till second degree relatives pancreatic cancer targeted therapy IHC imunohistochemical and genetic testing should be considered in those with HNPCC hereditary nonpolyposis colorectal cancer - like in Lynch syndrome with its variant -  Turcot patients with MMR - mismatch repair gene mutations metastatic cancer hereditary brain tumoursand Muir-Torre syndrome MTS - cutaneous gland tumours like keratoacanthomas and sebaceous  tumors associated with colon, breast, and genitourinary tract neoplasia.

Guaiac FOBT: is used to detect a part of the blood metastatic cancer hereditary hemoglobin. It requires avoidance of certain food before testing red meat.

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FIT: implies use of antibodies to detect human hemoglobin specifically. No dietary restrictions are needed. Studies suggest metastatic cancer hereditary every year beginning with the age of 50 until 80 years; it helps reduce death from CCR by up to 33 percent 8,9.

Sigmoidoscopy has the advantage of visualizing the rectum and sigmoid colon and being able to biopsy suspect lesions. Preparation for the test is less demanding than that needed for colonoscopy.

Prevenirea cancerului prin intermediul unor programe de screening

Trials have shown an up to 70 percent lowered risk of death from cancer of sigmoid and rectum using this method. A randomized study showed that just one sigmoidoscopy done metastatic cancer hereditary 55 and 64 years old metastatic cancer hereditary offer an important reduction in CCR incidence and mortality. The usual recommendation is for the test to be done every 5 years in conjunction with FOBT every 3 years Colonoscopy examines the whole colon and rectum. A form of sedation is recommended for patient comfort.

PMS2 TP53 APC — gena care codifica pentru o proteina cu rol critic in diferite procese celulare, actionand ca un supresor al cresterii tumorale. AXIN2 — gena metastatic cancer hereditary codifica pentru o proteina implicata in calea de semnalizare Wnt cu rol in diferite procese celulare inclusiv in cele de reparare a leziunilor ADN. Mutatii la nivelul genei AXIN2 determina aparitia carcinomului colonic si al sindromului care metastatic cancer hereditary Oligodontia si Cancerul colorectal BAP1 — gena ce codifica pentru o proteina numita ubiquitin — carboxi terminal hidrolaza care actioneaza prin indepartarea moleculelor de ubiquitina de pe alte protein, ducand la activarea acestora.

A more complex cleaning of the colon is needed before the investigation. It metastatic cancer hereditary the advantage of biopsy, too. Death from CCR is reduced by about 70 percent. The usual recommendation of testing is at 10 years, as long as other tests are negative Double-contrast barium enema : less sensitive than colonoscopy for detecting metastatic cancer hereditary polyps and cancers; has metastatic cancer hereditary utility for those who cannot undergo colonoscopy.

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New screening tests are under investigation: stool DNA testing trials showed a high rate of false positivesvirtual colonoscopy and capsule endoscopy; they should not yet be used for screening. Metastatic cancer hereditary had two arms: one used low dose helical CT and the other, standard chest X ray. On average over the three rounds of screening exams, The results showed that using the CT screening t­here is a 15 to 20 percent lower risk of dying from lung can­cer when compared with chest X ray.

The adenocarcinomas and squamous types were the most frequently detected, while small cell lung cancer, known for its agresivity, was infrequently found on either CT or chest X ray Mammography Metastatic cancer hereditary screening test for breast cancer has been shown to reduce mortality from the disease in women aged 40 to 74, especially in those aged 50 or older. To date, no differences are between classic film mammography and the digital one.

Women with breast implants should continue to have mammograms. A special technique called implant displacement views may be used.

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Modern metastatic cancer hereditary require a very small amount of radiation.