The aim of this study is a retrospective analysis of the spectrum of ovarian tumors: statistics, epidemiology and pathological features, based on one-year experience in our hospital. Materials and method. We analyzed 58 cases registered in the Pathology Department as ovarian cancer or cyst or hysterectomy specimens diagnosed with ovarian tumors, including benign, borderline and malignant tumors of various histological types. Based on their tumoral behavior, we had: three cases of benign tumors, all of them associated with a different histological tumor type and grade in the contralateral ovary, 12 cases of borderline tumors and 46 cases of malignant tumors 39 cases of primary and 7 cases of secondary tumors.
The most frequent histologic type was represented by high-grade serous carcinoma Rare primary ovarian tumors were represented by: adult granulosa cell tumor, clear cell carcinoma, mixed serous-mucinous carcinoma and undifferentiated pleomorphic sarcoma 1.
The earliest age of all patients with ovarian tumors was 31 years old ovarian cancer or cyst the mixed serous-mucinous carcinoma. Mean age distribution was 52 years old for benign tumors, 51 years old for borderline and 60 years old for malignant tumors.
Studiu clinico-patologic al tumorilor ovariene - experienţa de un an într-un centru medical
Primary malignant tumors are the most frequent type of ovarian tumors and their age incidence ranges from the third to the eighth decade. The majority of secondary ovarian tumors are of endometrial ovarian cancer or cyst. Keywords ovarian tumors, benign, borderline, malignant Rezumat Obiectiv. Scopul acestui studiu este analiza retrospectivă a spectrului de tumori ovariene, din punct de vedere ovarian cancer or cyst, epidemiologic şi al caracteristicilor histopatologice, reprezentând experienţa de un an în spitalul nostru Materiale şi metodă.
Am analizat 58 de cazuri, din Departamentul de Anatomie Patologică, înregistrate ca piese de ooforectomie sau histerectomie diagnosticate cu tumori ovariene, cuprinzând diferite tipuri histologice de tumori ovariene benigne, borderline şi maligne. În funţie de caracterul tumoral, am identificat: trei cazuri de tumori benigne, toate asociate cu un alt tip histologic tumoral în ovarul contralateral, 12 cazuri de tumori borderline şi 46 de cazuri de tumori maligne dintre care 39 de cazuri de tumori primare şi 7 cazuri reprezentând tumori secundare.
Vârsta minimă în rândul tuturor pacientelor cu tumori ovariene a fost 31 de ani. Vârsta medie pe categorii a fost 52 de ani pentru cancer sange in urina benigne, 51 de ani pentru tumori borderline şi 60 de ani pentru tumori maligne.
Traducere "ovarian" în română
Tumorile maligne primare reprezintă cel mai frecvent tip de tumori ovariene, cu o incidenţă de vârstă cuprinsă între decadele a treia şi a opta de viaţă. Majoritatea tumorilor ovariene secundare sunt ovarian cancer or cyst origine endometrială.
The relative frequency of ovarian tumor is different for western and Asian countries. Two third of ovarian tumors occur in women of reproductive age group 1. Borderline tumors occur at slightly older ages and malignant tumors are more common in women between 45 and 65 years old 2.
Ovarian cancer represents the fifth cause of cancer and the fifth cause of death due to cancer in females in the European Union 3. There are three major histologic subtypes of surface epithelial tumors: serous, mucinous and endometrioid.
Serous carcinomas are divided in: high-grade serous carcinoma and low-grade serous carcinoma. These tumors are associated with KRAS mutation mainly, and smoking is a risk factor, not associated with serous tumors. Mucinos tumors are composed of gastrointestinal type cell containing intracytoplasmic mucin and therefore, malignant tumors should always be carefully examined for excluding metastatic tumors with similar morphology 2,5.
Chistul ovarian impotență
Endometrioid tumors of the ovary are similar to endometrioid tumors of the endometrium. Other rare epithelial tumors include: clear cell tumors, Brenner tumors, mixed serous-mucinous or mixed epithelial-mesenchymal tumors. The group includes: teratomas mature, immature and monodermal or highly specializeddysgerminoma, Yolk-sac tumor, non-gestational chorio-carcinoma, embryonal carcinoma and mixed tumors.
In this group, only mature teratomas and ovarian cancer or cyst teratoma - benign struma ovarii are benign tumors.
Several conditions are more frequent in pregnancy: appendicitis, cholecystitis, adnexal torsion, adnexal mass, trauma, breast disease, cervical dysplasia or cancer, bowel obstruction. When a pregnant patient has to undergo surgery, the obstetrician, the general surgeon, or the orthopedist, the neurosurgeon as appropriate, together with the anesthetist and the neonatologist must consult each other, establishing the plan of action and performing accordingly. Among all procedures, abdominal interventions have the most significant impact, either considering laparotomy, or laparoscopy. There are several advantages of laparoscopic surgery during pregnancy: decreased pain, smaller abdominal incisions, smaller scars, fewer incisional hernias, shorter recovery and hospitalization time, early normal bowel function and mobilization.
Sex-cord stromal tumors include neoplasms that contain granulosa cells, theca cells, fibloblasts, Sertoli cells and Leydig cells, which are derived from ovarian stroma, that is formed from sex cords under the influences of coelomic and mesonephric epithelium. This type of tumor has clinical importance because of its potential to elaborate large amounts of estrogens and because it has malignant potential. Pure fibromas are hormonally inactive; Sertoli and Leydig cell tumors are active and have masculinizing or de-feminization effects 5,7.
Metastases derived from non-gynecological sites are eleven times more frequent than those derived from female genital organs, the gastrointestinal tract being the most common origin 7.
Tumors from the stomach, colon, and breast are the three most common neoplasms that metastasize to the ovary 8. Materials and method We performed a retrospective analysis of ovarian ovarian cancer or cyst cases registered at the Pathology Department of ovarian cancer or cyst Bucharest Emergency University Hospital for a period of one year.
Ovarian Cysts vs Ovarian Tumors (Ovarian Cancer Information)
The study included 58 cases of oophorectomy, salpingo-oophorectomy or hysterectomy specimens diagnosed with benign, borderline or malignant tumors of various histologic types. We classified them according to their morphologic features, we analyzed the age distribution for each category, the clinical ovarian cancer or cyst, regional spread, lymph nodes status, peritoneal involvement or metastases in available cases; the follow-up was possible in a limited number of cases.
All data was obtained from medical records and from the Statistics Department of University Emergency Hospital in Bucharest.
Results and discussions Based on their tumoral behavior, we had Figure 1 : three cases 4. In our ovarian cancer or cyst we found a smaller prevalence of benign tumors of only 4. Figure 1. The distribution of ovarian tumors over a period of one year The most frequent histologic type among all ovarian tumors was represented by high-grade serous carcinoma Mucinous carcinoma accounted for Studies of molecular alteration have suggested that this tumors do actually progress from endometriosis 4, We had one case of poorly differentiated carcinoma of unknown origin.
Laparoscopic gynecological procedures during pregnancy
All the metastasis cases were large excision specimens and were integrated in the clinico-pathological context.
The gynecological origin is usually less frequent than the gastrointestinal origin, which is the first cause of ovarian metastasis 7,8, Rare primary ovarian tumors were represented by: adult granulosa cell tumor Figure 2clear cell carcinoma, mixed serous-mucinous carcinoma, and undifferentiated pleomorphic sarcoma 1. Figure 2. Intraoperative Amacroscopic B and microscopic C aspect of a voluminous left ovarian cyst in a patient of 60 years old; after the histopathological analysis the diagnose was adult granulosa cell tumor - note the micro-follicular pattern The earliest age of a patient with ovarian tumor was 31 years old for the mixed serous-mucinous carcinoma, a younger age than mean age for this type of tumor, but cases of patients within 16 to 79 years had been previously reported 13, Mean age distribution was: 52 years old for benign tumors, with a range of 45 to 67 years old; 51 years old for borderline tumors, with a range of 32 to 73 years old; 60 years old for malignant tumors, with papiloma uvula cancer range of 31 to 83 years old Figure 3.
Mean age distribution in the category of malignant tumors is shown in Figure 4. We found a higher age range for benign tumors, ovarian cancer ovarian cancer or cyst cyst considering the fact that they were associated with borderline tumors, we found it acceptable 2,4.
Figure 3. Age range distribution according to the ovarian cancer or cyst of tumor Ovarian cancer or cyst 4. Mean age distribution among malignant ovarian tumors We had two cases of tumoral recurrence with multiple metastases of previous high-grade serous carcinoma in patients of 62 and 70 years old, respectively, and one deceased patient of 75 years old, with undifferentiated pleomorphic sarcoma.
They are highly aggressive tumors with poor prognosis, and can develop in younger patients as well. Kurtoglu et al.
The most encountered manifestations were: moderate to severe abdominal pain, distention, ascites and anorexia for malignant tumors and mild abdominal distension and menstrual disorders for borderline together with benign tumors. The symptoms are usually found in large tumors 16, The treatment of ovarian cancer with molecular targeting therapy, platinum and taxane containing chemotherapy and other specific drugs has improved the prognosis over time Currently, the standard primary therapy for advanced disease involves a combination of maximal cytoreductive surgery and chemotherapy with carboplatin plus paclitaxel or with carboplatin alone.
Despite initial high response ovarian cancer or cyst, a large proportion of patients relapse, resulting in a therapeutic challenge 19, Because these patients are not curable, the goal of therapy becomes the improvement in both quality and length of life. Single-agent paclitaxel, topotecan, or pegylated liposomal doxorubicin have demonstrated activity in this patient population and are reasonable treatment options 19, Conclusions In our study, primary malignant tumors are the most frequent type of ovarian tumors and their age incidence ranges from the third to the eighth decade.
We found higher prevalence rates for high-grade serous carcinomas. The majority of secondary ovarian tumors we studied were of endometrial human papillomavirus genital ulcers, which may suggest that gynecological primary situs can be considered of greater potential of spreading to the ovaries than previously thought.
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A case report and review of the literature. Eur J Gynaecol Oncol.
Home Chistul ovarian impotență Unless all ovarian cyst contributing factors are addressed by following the holistic approach, ovarian cancer or cyst most cases, you will not be able to prevent the recurrence of ovarian cysts and their potential. They actually have to squeezed me in their schedule since the hospital is fully booked. Ovarian suppression is the term used to describe treatments that stop the ovaries from making oestrogen, either permanently or temporarily.
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Proceduri ginecologice laparoscopice în timpul sarcinii
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A clinical-pathological study of ovarian tumors - one-year center experience
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- Studiu clinico-patologic al tumorilor ovariene - experienţa de un an într-un centru medical
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