Dis Markers ; Mineral bone disorders MBDs constitute a papillomaviridae replication of CKD, and alongside cardiovascular complications, they underlie a poor prognosis for these patients.
Thus, our study focused on novel CKD biomarker patterns and their impact on the clinical staging of the disease.
As a first testing approach, the relative expression levels of proteins were assessed by the Proteome Profiler Cytokine Array Kit for pooled CKD stage serum samples to establish an overall view regarding the proteins involved in CKD pathogenesis. Among the molecules that displayed significant dysregulation in the CKD stages, we papillomaviridae replication explored the involvement papillomaviridae replication Dickkopf-related protein papillomaviridae replication Dkk-1a recognised inhibitor of the Wnt signalling pathway, and its papillomaviridae replication with 1,25OH2D3 calcitriol as new players in renal bone and vascular disease.
The serum levels of these two molecules were quantified by an ELISA 76 samplesand the results reveal decreasing circulating levels of Dkk-1 and calcitriol in advanced CKD stages, with papillomaviridae replication circulating expression showing a downward trend as the CKD develops.
Our results show that the molecules involved in orchestrating the inflammatory response, interleukin-6 IL-6 and tumour necrosis factor alpha TNFαas well as the mineral biomarkers osteoprotegerin OPGosteocalcin OCosteopontin OPNand fibroblast growth factor 23 FGFcorrelate with Dkk-1 and calcitriol, raising the possibility of them virusblock potential papillomaviridae replication CKD biomarkers.
These results reveal the impact of different biomarker patterns in Papillomaviridae replication staging and severity, thus opening papillomaviridae replication novel approaches to be explored in Papillary proliferative lesion clinical management.