The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated. The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a cervical cancer with hysterectomy of evaluation the response to neoadjuvant therapy and its prognostic significance. The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy. Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness.
Corresponding author: Dr. Maria Alexandra Barbu, e-mail: m.
There is a strong link between the presence of human papillomavirus HPV cervical cancer and its precursors. All patients diagnosed with invasive cervical carcinoma should be evaluated clinically by vaginal exam and rectal imaging by computed tomography, magnetic resonance imaging or PET-CT.
FIGO system is most widely used staging system for cervical cancer. FIGO staging system is mainly based on clinical examination, pelvic examination therefore performed by a clinician with experience, which is critically important.
Basically, in micro invasive cervical cancer with hysterectomy std. IA1 the treatment of choice is conservative surgery excisional conisation or hysterectomy extra fasciala.
Robotic Radical Hysterectomy for Cervical Cancer
In invasive cancers in early stages std. IA2, IB1, some IIA the treatment of choice is radical hysterectomy or modified radical hysterectomy, radical trachelectomia if desired fertility preservation or radiotherapy.
In locally advanced cancers std. IB2 to IVA the treatment of choice is radio chemotherapy. Treatment of patients with metastatic disease is primarily systemic chemotherapy, but the patients are encouraged to participate in clinical trials. If you already subscribed, please login here.
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